Propafenone treatment of supraventricular tachycardia 47 cases

Supraventricular tachycardia (paroxysmal supraventricular tachycarelia, PSVT) is a common clinical arrhythmia, severe PSVT can lead to heart failure, shock, the immediate termination of their attack is one of the main purposes treatment. Author June 1994 - 1999-1 measurements on pacemaker therapy PSTV47 cases, better results are reported as follows.
1 clinical data
General information on 47 cases of 110 patients, male 30 cases, 17 cases of female, age 18 - 71 years old. Hypertensive patients with coronary heart disease 21 cases, seven cases of rheumatic heart disease, Wolff - Parkinson-White Syndrome eight cases, 11 cases of unknown causes. ECG showed: QRS complex rules, frequency 150 - 250 times. Min. The author of 14 cases repeatedly, the largest one case of recurrent eight, the incidence to appointments to 4 mi - 13h range. Suddenly flustered for the clinical manifestations, chest tightness, lightheadedness, heart palpitations, shortness of breath; ECG with PSVT performance. Conventional carotid sinus massage, oppression eyeball and posterior pharyngeal stimulation are invalid.
1.2 ECG monitor treatment under propafenone 7 mg +10 20% glucose injection, intravenous injection, the time> 10 min, PSVT termination of suspended substances; Repeat the above may be invalid if the dosage 2 h, the total does not exceed 250 mg.
1.3 efficacy standard medication within 1 h 3 h to sinus rhythm and no recurrence for the effective, in a specified time, the failure to law or law shortly after the recurrence were invalid.
1.4 Results The 47 cases of 44 cases of effective, efficient 93.6%, rhythm calm Note 1 (≤ 70 mg) were 42 cases, to the legal time 5 - 14 minutes, with an average of 8.77 +5. Olmin; One case of application to propafenone after the legal transfer of 140 mg, at 26 min; one case of drug law to 200 mg, at 44 min. Three cases of propafenone to 250 mg3h law has yet to give up propafenone treatment programs. After administration obviously does not apply to 16 cases, of which 14 cases of nausea and vomiting, blood pressure dropped an average of 0.5 - 3.5 kPa six cases, in the four cases of premature beat, with sedation, and other symptomatic treatment shortly after symptoms ease.
2 discussion
Rhythm-ping is the only country capable of producing the type of IC antiarrhythmic drugs, antiarrhythmic broad spectrum of high and fast onset of action, side effects. Its main role of electrophysiology: (1) inhibit the action potential of the speed and magnitude; (2) blocking myocardial cells quickly satisfied that ion channels; (3) extend the action potential duration and effective refractory period; (4) inhibition of Pu's fiber spontaneous Except for a four rate. PSVT mechanism is returned, self-discipline and trigger increased activity. Propafenone for the electrophysiological basis of PSVT is inhibited bypass conduction, inhibit conduction stronger than before to reverse conduction, should not be extended to the period before. Based on the above theory author of rhythm in the treatment of PSVT, to the law are found in patients with progressive heart rate slowed down to the form 150. Min, and then there were 11 cases of 1 to sinus rhythm, Ms are to gradually drop to sinus rhythm. PSTV to sinus rhythm in the two cases when suddenly stopped Bo sinus, the immediate chest cardiac massage was sinus rhythm. When the rhythm is still in the application carefully, mind, and under the temporary care with necessary rescue drugs.